Um novo trabalho encontrou depressão maior aumentava o risco de morbidade e mortalidade cardiovascular em mulheres que participaram do Nurses' Health Study [1]. O hazard ratios foi maior para eventos fatais e direcionados pela associação com depressão - em particular aqueles que usavam anti-depressivo - com morte súbita. Dr William Whang (Columbia University, New York, NY) relataram seus achados em Março/2009 do Journal of the American College of Cardiology.
Mas os autores concluem que, no momento, os benfícios do uso correto de anti-depressivos supera o risco de morte súbita. "The absence of proof that antidepressants might cause cardiac events is more relevant than conclusive proof that this effect is absent. Nevertheless, these findings are sufficiently sobering to warrant heightened clinical surveillance and to initiate studies to definitively address this relationship," disse Drs Sanjiv M Narayan e Murray B Stein (University of California, San Diego [UCSD]) no editorial que acompanha o artigo [2].
Whang W, Kubzansky LD, Kawachi I, et al. Depression and risk of sudden cardiac death and coronary heart disease in women. Results from the Nurses' Health Study. J Am Coll Cardiol 2009; 53:950-958
Narayan SM and Stein MB. Do depression or antidepressants increase cardiovascular mortality? The absence of proof might be more important than the proof of absence. J Am Coll Cardiol 2009; 53:959-961
Dryden J. Depression increases risk for heart disease more than genetics or environment [press release]. March 3, 2009. Available at: http://www.theheart.org/article/viewDocument.do?document=http%3A%2F%2Fmednews.wustl.edu%2Fnews%2Fpage%2Fnormal%2F13643.html%3FemailID%3D23300.
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